HydroWASTE is a spatially explicit global database of 58,502 wastewater treatment plants (WWTPs) and their characteristics. This database was developed by combining national and regional datasets with auxiliary information to derive or complete missing characteristics, including the amount of people served, the flow rate of effluents, and the level of treatment of processed wastewater. The HydroSHEDS river network with streamflow estimates was used to geo-reference plant outfall locations and to assess the distribution of wastewaters at a global scale. All wastewater treatment plants are co-registered to the global river network of the HydroRIVERS database via their estimated outfall locations.