'''DEFINITION''' The sea level ocean monitoring indicator has been presented in the Copernicus Ocean State Report #8. The sea level ocean monitoring indicator is derived from the DUACS delayed-time (DT-2024 version, “my” (multi-year) dataset used when available) sea level anomaly maps from satellite altimetry based on a stable number of altimeters (two) in the satellite constellation. The product is distributed by the Copernicus Climate Change Service and the Copernicus Marine Service (SEALEVEL_GLO_PHY_CLIMATE_L4_MY_008_057). At each grid point, the trends/accelerations are estimated on the time series corrected from regional GIA correction (GIA map of a 27 ensemble model following Spada et Melini, 2019) and adjusted from annual and semi-annual signals. Regional uncertainties on the trends estimates can be found in Prandi et al., 2021. '''CONTEXT''' Change in mean sea level is an essential indicator of our evolving climate, as it reflects both the thermal expansion of the ocean in response to its warming and the increase in ocean mass due to the melting of ice sheets and glaciers(WCRP Global Sea Level Budget Group, 2018). According to the IPCC 6th assessment report (IPCC WGI, 2021), global mean sea level (GMSL) increased by 0.20 [0.15 to 0.25] m over the period 1901 to 2018 with a rate of rise that has accelerated since the 1960s to 3.7 [3.2 to 4.2] mm/yr for the period 2006–2018. Human activity was very likely the main driver of observed GMSL rise since 1970 (IPCC WGII, 2021). The weight of the different contributions evolves with time and in the recent decades the mass change has increased, contributing to the on-going acceleration of the GMSL trend (IPCC, 2022a; Legeais et al., 2020; Horwath et al., 2022). At regional scale, sea level does not change homogenously, and regional sea level change is also influenced by various other processes, with different spatial and temporal scales, such as local ocean dynamic, atmospheric forcing, Earth gravity and vertical land motion changes (IPCC WGI, 2021). The adverse effects of floods, storms and tropical cyclones, and the resulting losses and damage, have increased as a result of rising sea levels, increasing people and infrastructure vulnerability and food security risks, particularly in low-lying areas and island states (IPCC, 2019, 2022b). Adaptation and mitigation measures such as the restoration of mangroves and coastal wetlands, reduce the risks from sea level rise (IPCC, 2022c). '''KEY FINDINGS''' The altimeter sea level trends over the [1999/02/20 to 2024/11/19] period exhibit large-scale variations with trends up to +10 mm/yr in regions such as the western tropical Pacific Ocean. In this area, trends are mainly of thermosteric origin (Legeais et al., 2018; Meyssignac et al., 2017) in response to increased easterly winds during the last two decades associated with the decreasing Interdecadal Pacific Oscillation (IPO)/Pacific Decadal Oscillation (e.g., McGregor et al., 2012; Merrifield et al., 2012; Palanisamy et al., 2015; Rietbroek et al., 2016). Prandi et al. (2021) have estimated a regional altimeter sea level error budget from which they determine a regional error variance-covariance matrix and they provide uncertainties of the regional sea level trends. Over 1993-2019, the averaged local sea level trend uncertainty is around 0.83 mm/yr with local values ranging from 0.78 to 1.22 mm/yr. '''DOI (product):''' https://doi.org/10.48670/moi-00238

'''This product has been archived''' '''DEFINITION''' The CMEMS IBI_OMI_tempsal_extreme_var_temp_mean_and_anomaly OMI indicator is based on the computation of the annual 99th percentile of Sea Surface Temperature (SST) from model data. Two different CMEMS products are used to compute the indicator: The Iberia-Biscay-Ireland Multi Year Product (IBI_MULTIYEAR_PHY_005_002) and the Analysis product (IBI_ANALYSISFORECAST_PHY_005_001). Two parameters have been considered for this OMI: • Map of the 99th mean percentile: It is obtained from the Multi Year Product, the annual 99th percentile is computed for each year of the product. The percentiles are temporally averaged over the whole period (1993-2021). • Anomaly of the 99th percentile in 2022: The 99th percentile of the year 2022 is computed from the Analysis product. The anomaly is obtained by subtracting the mean percentile from the 2022 percentile. This indicator is aimed at monitoring the extremes of sea surface temperature every year and at checking their variations in space. The use of percentiles instead of annual maxima, makes this extremes study less affected by individual data. This study of extreme variability was first applied to the sea level variable (Pérez Gómez et al 2016) and then extended to other essential variables, such as sea surface temperature and significant wave height (Pérez Gómez et al 2018 and Alvarez Fanjul et al., 2019). More details and a full scientific evaluation can be found in the CMEMS Ocean State report (Alvarez Fanjul et al., 2019). '''CONTEXT''' The Sea Surface Temperature is one of the essential ocean variables, hence the monitoring of this variable is of key importance, since its variations can affect the ocean circulation, marine ecosystems, and ocean-atmosphere exchange processes. As the oceans continuously interact with the atmosphere, trends of sea surface temperature can also have an effect on the global climate. While the global-averaged sea surface temperatures have increased since the beginning of the 20th century (Hartmann et al., 2013) in the North Atlantic, anomalous cold conditions have also been reported since 2014 (Mulet et al., 2018; Dubois et al., 2018). The IBI area is a complex dynamic region with a remarkable variety of ocean physical processes and scales involved. The Sea Surface Temperature field in the region is strongly dependent on latitude, with higher values towards the South (Locarnini et al. 2013). This latitudinal gradient is supported by the presence of the eastern part of the North Atlantic subtropical gyre that transports cool water from the northern latitudes towards the equator. Additionally, the Iberia-Biscay-Ireland region is under the influence of the Sea Level Pressure dipole established between the Icelandic low and the Bermuda high. Therefore, the interannual and interdecadal variability of the surface temperature field may be influenced by the North Atlantic Oscillation pattern (Czaja and Frankignoul, 2002; Flatau et al., 2003). Also relevant in the region are the upwelling processes taking place in the coastal margins. The most referenced one is the eastern boundary coastal upwelling system off the African and western Iberian coast (Sotillo et al., 2016), although other smaller upwelling systems have also been described in the northern coast of the Iberian Peninsula (Alvarez et al., 2011), the south-western Irish coast (Edwars et al., 1996) and the European Continental Slope (Dickson, 1980). '''CMEMS KEY FINDINGS''' In the IBI region, the 99th mean percentile for 1993-2021 shows a north-south pattern driven by the climatological distribution of temperatures in the North Atlantic. In the coastal regions of Africa and the Iberian Peninsula, the mean values are influenced by the upwelling processes (Sotillo et al., 2016). These results are consistent with the ones presented in Álvarez Fanjul (2019) for the period 1993-2016. The analysis of the 99th percentile anomaly in the year 2023 shows that this period has been affected by a severe impact of maximum SST values. Anomalies exceeding the standard deviation affect almost the entire IBI domain, and regions impacted by thermal anomalies surpassing twice the standard deviation are also widespread below the 43ºN parallel. Extreme SST values exceeding twice the standard deviation affect not only the open ocean waters but also the easter boundary upwelling areas such as the northern half of Portugal, the Spanish Atlantic coast up to Cape Ortegal, and the African coast south of Cape Aguer. It is worth noting the impact of anomalies that exceed twice the standard deviation is widespread throughout the entire Mediterranean region included in this analysis. '''DOI (product):''' https://doi.org/10.48670/moi-00254

'''This product has been archived''' For operational and online products, please visit https://marine.copernicus.eu '''Short description:''' For the '''North Atlantic''' Ocean '''Satellite Observations''', Plymouth Marine Laboratory (PML) is providing '''Bio-Geo_Chemical (BGC)''' products based on the ESA-CCI reflectance inputs. * Upstreams: SeaWiFS, MODIS, MERIS, VIIRS-SNPP, OLCI-S3A & OLCI-S3B for the '''""multi""''' products, and S3A & S3B only for the '''""olci""''' products. * Variables: Chlorophyll-a ('''CHL''') and Diffuse Attenuation ('''KD490'''). * Temporal resolutions:'''monthly'''. * Spatial resolutions: '''1 km''' (multi) or '''300 meters''' (olci). * Recent products are organized in datasets called Near Real Time ('''NRT''') and long time-series (from 1997) in datasets called Multi-Years ('''MY'''). To find these products in the catalogue, use the search keyword '''""ESA-CCI""'''. '''DOI (product) :''' https://doi.org/10.48670/moi-00285

'''This product has been archived''' '''DEFINITION''' Estimates of Ocean Heat Content (OHC) are obtained from integrated differences of the measured temperature and a climatology along a vertical profile in the ocean (von Schuckmann et al., 2018). The regional OHC values are then averaged from 60°S-60°N aiming i) to obtain the mean OHC as expressed in Joules per meter square (J/m2) to monitor the large-scale variability and change. ii) to monitor the amount of energy in the form of heat stored in the ocean (i.e. the change of OHC in time), expressed in Watt per square meter (W/m2). Ocean heat content is one of the six Global Climate Indicators recommended by the World Meterological Organisation for Sustainable Development Goal 13 implementation (WMO, 2017). '''CONTEXT''' Knowing how much and where heat energy is stored and released in the ocean is essential for understanding the contemporary Earth system state, variability and change, as the ocean shapes our perspectives for the future (von Schuckmann et al., 2020). Variations in OHC can induce changes in ocean stratification, currents, sea ice and ice shelfs (IPCC, 2019; 2021); they set time scales and dominate Earth system adjustments to climate variability and change (Hansen et al., 2011); they are a key player in ocean-atmosphere interactions and sea level change (WCRP, 2018) and they can impact marine ecosystems and human livelihoods (IPCC, 2019). '''CMEMS KEY FINDINGS''' Since the year 2005, the upper (0-2000m) near-global (60°S-60°N) ocean warms at a rate of 1.0 ± 0.1 W/m2. Note: The key findings will be updated annually in November, in line with OMI evolutions. '''DOI (product):''' https://doi.org/10.48670/moi-00235

'''This product has been archived''' "''DEFINITION''' Marine primary production corresponds to the amount of inorganic carbon which is converted into organic matter during the photosynthesis, and which feeds upper trophic layers. The daily primary production is estimated from satellite observations with the Antoine and Morel algorithm (1996). This algorithm modelized the potential growth in function of the light and temperature conditions, and with the chlorophyll concentration as a biomass index. The monthly area average is computed from monthly primary production weighted by the pixels size. The trend is computed from the deseasonalised time series (1998-2022), following the Vantrepotte and Mélin (2009) method. The trend estimate is not shown because the length of the time series does not allow to completely differentiate the climate trend to the natural variability of the primary production. More details are provided in the Ocean State Reports 4 (Cossarini et al. ,2020). '''CONTEXT''' Marine primary production is at the basis of the marine food web and produce about 50% of the oxygen we breath every year (Behrenfeld et al., 2001). Study primary production is of paramount importance as ocean health and fisheries are directly linked to the primary production (Pauly and Christensen, 1995, Fee et al., 2019). Changes in primary production can have consequences on biogeochemical cycles, and specially on the carbon cycle, and impact the biological carbon pump intensity, and therefore climate (Chavez et al., 2011). Despite its importance for climate and socio-economics resources, primary production measurements are scarce and do not allow a deep investigation of the primary production evolution over decades. Satellites observations and modelling can fill this gap. However, depending of their parametrisation, models can predict an increase or a decrease in primary production by the end of the century (Laufkötter et al., 2015). Primary production from satellite observations presents therefore the advantage to dispose an archive of more than two decades of global data. This archive can be assimilated in models, in addition to direct environmental analysis, to minimise models uncertainties (Gregg and Rousseaux, 2019). In the Ocean State Reports 4, primary production estimate from satellite and from modelling are compared at the scale of the Mediterranean Sea. This demonstrates the ability of such a comparison to deeply investigate physical and biogeochemical processes associated to the primary production evolution (Cossarini et al., 2020) '''CMEMS KEY FINDINGS''' Global primary production does not show specific trend and remain relatively constant over the archive 1998-2022. The temporal variability of the primary production appears to be mainly driven by the seasonal variation. However, some specific inter-annual event may induce noticeable increase or decrease in primary production, as for example in the second part of 2011. '''DOI (product):''' https://doi.org/10.48670/moi-00225

'''This product has been archived''' For operationnal and online products, please visit https://marine.copernicus.eu '''Short description:''' The Global Ocean Satellite monitoring and marine ecosystem study group (GOS) of the Italian National Research Council (CNR), in Rome, distributes Level-4 product including the daily interpolated chlorophyll field with no data voids starting from the multi-sensor (MODIS-Aqua, NOAA-20-VIIRS, NPP-VIIRS, Sentinel3A-OLCI at 300m of resolution) (at 1 km resolution) and the monthly averaged chlorophyll concentration for the multi-sensor (at 1 km resolution) and Sentinel-OLCI Level-3 (at 300m resolution). Chlorophyll field are obtained by means of the Mediterranean regional algorithms: an updated version of the MedOC4 (Case 1 waters, Volpe et al., 2019, with new coefficients) and AD4 (Case 2 waters, Berthon and Zibordi, 2004). Discrimination between the two water types is performed by comparing the satellite spectrum with the average water type spectral signature from in situ measurements for both water types. Reference insitu dataset is MedBiOp (Volpe et al., 2019) where pure Case II spectra are selected using a k-mean cluster analysis (Melin et al., 2015). Merging of Case I and Case II information is performed estimating the Mahalanobis distance between the observed and reference spectra and using it as weight for the final merged value. The interpolated gap-free Level-4 Chl concentration is estimated by means of a modified version of the DINEOF algorithm by GOS (Volpe et al., 2018). DINEOF is an iterative procedure in which EOF are used to reconstruct the entire field domain. As first guess, it uses the SeaWiFS-derived daily climatological values at missing pixels and satellite observations at valid pixels. The other Level-4 dataset is the time averages of the L3 fields and includes the standard deviation and the number of observations in the monthly period of integration. '''Processing information:''' Multi-sensor products are constituted by MODIS-AQUA, NOAA20-VIIRS, NPP-VIIRS and Sentinel3A-OLCI. For consistency with NASA L2 dataset, BRDF correction was applied to Sentinel3A-OLCI prior to band shifting and multi sensor merging. Hence, the single sensor OLCI data set is also distributed after BRDF correction. Single sensor NASA Level-2 data are destriped and then all Level-2 data are remapped at 1 km spatial resolution (300m for Sentinel3A-OLCI) using cylindrical equirectangular projection. Afterwards, single sensor Rrs fields are band-shifted, over the SeaWiFS native bands (using the QAAv6 model, Lee et al., 2002) and merged with a technique aimed at smoothing the differences among different sensors. This technique is developed by The Global Ocean Satellite monitoring and marine ecosystem study group (GOS) of the Italian National Research Council (CNR, Rome). Then geophysical fields (i.e. chlorophyll, kd490, bbp, aph and adg) are estimated via state-of-the-art algorithms for better product quality. Level-4 includes both monthly time averages and the daily-interpolated fields. Time averages are computed on the delayed-time data. The interpolated product starts from the L3 products at 1 km resolution. At the first iteration, DINEOF procedure uses, as first guess for each of the missing pixels the relative daily climatological pixel. A procedure to smooth out spurious spatial gradients is applied to the daily merged image (observation and climatology). From the second iteration, the procedure uses, as input for the next one, the field obtained by the EOF calculation, using only a number of modes: that is, at the second round, only the first two modes, at the third only the first three, and so on. At each iteration, the same smoothing procedure is applied between EOF output and initial observations. The procedure stops when the variance explained by the current EOF mode exceeds that of noise. '''Description of observation methods/instruments:''' Ocean colour technique exploits the emerging electromagnetic radiation from the sea surface in different wavelengths. The spectral variability of this signal defines the so-called ocean colour which is affected by the pre+D2sence of phytoplankton. '''Quality / Accuracy / Calibration information:''' A detailed description of the calibration and validation activities performed over this product can be found on the CMEMS web portal. '''Suitability, Expected type of users / uses:''' This product is meant for use for educational purposes and for the managing of the marine safety, marine resources, marine and coastal environment and for climate and seasonal studies. '''Dataset names:''' *dataset-oc-med-chl-multi-l4-chl_1km_monthly-rt-v02 *dataset-oc-med-chl-multi-l4-interp_1km_daily-rt-v02 *dataset-oc-med-chl-olci-l4-chl_300m_monthly-rt-v02 '''Files format:''' *CF-1.4 *INSPIRE compliant '''DOI (product) :''' https://doi.org/10.48670/moi-00113

'''This product has been archived''' '''DEFINITION''' The temporal evolution of thermosteric sea level in an ocean layer is obtained from an integration of temperature driven ocean density variations, which are subtracted from a reference climatology to obtain the fluctuations from an average field. The regional thermosteric sea level values are then averaged from 60°S-60°N aiming to monitor interannual to long term global sea level variations caused by temperature driven ocean volume changes through thermal expansion as expressed in meters (m). '''CONTEXT''' Most of the interannual variability and trends in regional sea level is caused by changes in steric sea level. At mid and low latitudes, the steric sea level signal is essentially due to temperature changes, i.e. the thermosteric effect (Stammer et al., 2013, Meyssignac et al., 2016). Salinity changes play only a local role. Regional trends of thermosteric sea level can be significantly larger compared to their globally averaged versions (Storto et al., 2018). Except for shallow shelf sea and high latitudes (> 60° latitude), regional thermosteric sea level variations are mostly related to ocean circulation changes, in particular in the tropics where the sea level variations and trends are the most intense over the last two decades. '''CMEMS KEY FINDINGS''' Significant (i.e. when the signal exceeds the noise) regional trends for the period 2005-2019 from the Copernicus Marine Service multi-ensemble approach show a thermosteric sea level rise at rates ranging from the global mean average up to more than 8 mm/year. There are specific regions where a negative trend is observed above noise at rates up to about -8 mm/year such as in the subpolar North Atlantic, or the western tropical Pacific. These areas are characterized by strong year-to-year variability (Dubois et al., 2018; Capotondi et al., 2020). Note: The key findings will be updated annually in November, in line with OMI evolutions. '''DOI (product):''' https://doi.org/10.48670/moi-00241

'''DEFINITION''' Estimates of Ocean Heat Content (OHC) are obtained from integrated differences of the measured temperature and a climatology along a vertical profile in the ocean (von Schuckmann et al., 2018). The products used include three global reanalyses: GLORYS, C-GLORS, ORAS5 (GLOBAL_MULTIYEAR_PHY_ENS_001_031) and two in situ based reprocessed products: CORA5.2 (INSITU_GLO_PHY_TS_OA_MY_013_052) , ARMOR-3D (MULTIOBS_GLO_PHY_TSUV_3D_MYNRT_015_012). The regional OHC values are then averaged from 60°S-60°N aiming i) to obtain the mean OHC as expressed in Joules per meter square (J/m2) to monitor the large-scale variability and change. ii) to monitor the amount of energy in the form of heat stored in the ocean (i.e. the change of OHC in time), expressed in Watt per square meter (W/m2). Ocean heat content is one of the six Global Climate Indicators recommended by the World Meterological Organisation for Sustainable Development Goal 13 implementation (WMO, 2017). '''CONTEXT''' Knowing how much and where heat energy is stored and released in the ocean is essential for understanding the contemporary Earth system state, variability and change, as the ocean shapes our perspectives for the future (von Schuckmann et al., 2020). Variations in OHC can induce changes in ocean stratification, currents, sea ice and ice shelfs (IPCC, 2019; 2021); they set time scales and dominate Earth system adjustments to climate variability and change (Hansen et al., 2011); they are a key player in ocean-atmosphere interactions and sea level change (WCRP, 2018) and they can impact marine ecosystems and human livelihoods (IPCC, 2019). '''CMEMS KEY FINDINGS''' Regional trends for the period 2005-2023 from the Copernicus Marine Service multi-ensemble approach show warming at rates ranging from the global mean average up to more than 8 W/m2 in some specific regions (e.g. northern hemisphere western boundary current regimes). There are specific regions where a negative trend is observed above noise at rates up to about -5 W/m2 such as in the subpolar North Atlantic. These areas are characterized by strong year-to-year variability (Dubois et al., 2018; Capotondi et al., 2020). Note: The key findings will be updated annually in November, in line with OMI evolutions. '''DOI (product):''' https://doi.org/10.48670/moi-00236

'''Short description:''' Global sea ice thickness from merged L-Band radiometer (SMOS ) and radar altimeter (CryoSat-2, Sentinel-3A/B) observations during freezing season between October and April in the northern hemisphere and April to October in the southern hemisphere. The SMOS mission provides L-band observations and the ice thickness-dependency of brightness temperature enables to estimate the sea-ice thickness for thin ice regimes. Radar altimeters measure the height of the ice surface above the water level, which can be converted into sea ice thickness assuming hydrostatic equilibrium. '''DOI (product) :''' https://doi.org/10.48670/moi-00125

'''DEFINITION''' The indicator of Volume Transport Anomaly in Selected Vertical Sections in the Iberia–Biscay–Ireland (IBI) region (OMI_CIRCULATION_VOLTRANS_IBI_section_integrated_anomalies) is defined as the time series of annual mean volume transport calculated across a set of vertical ocean sections. These sections have been selected to represent the temporal variability of key ocean currents within the IBI domain. The monitored ocean currents include the transport towards the North Sea through the Rockall Trough (RTE) (Holliday et al., 2008; Lozier and Stewart, 2008), the Canary Current (CC) (Knoll et al., 2002; Mason et al., 2011), the Azores Current (AC) (Mason et al., 2011), the Algerian Current (ALG) (Tintoré et al., 1988; Benzohra and Millot, 1995; Font et al., 1998), and the net transport along the 48° N latitude parallel (N48) (see OMI figure). To produce ensemble-based results, six datasets provided by the Copernicus Marine Service have been used: * '''IBI-REA''' & '''IBI-INT''': IBI_MULTIYEAR_PHY_005_002 (reanalysis and interim datasets) * '''GLO-REA''': GLOBAL_MULTIYEAR_PHY_001_030 (reanalysis) * '''ARMOR''': MULTIOBS_GLO_PHY_TSUV_3D_MYNRT_015_012 (reprocessed observations) * '''MED-REA''': MEDSEA_MULTIYEAR_PHY_006_004 (reanalysis) * '''NWS-REA''': NWSHELF_MULTIYEAR_PHY_004_009 (reanalysis) The time series displays the ensemble mean (blue line), the ensemble spread (grey shaded area), and the mean transport with reversed sign (red dashed line), which indicates the threshold of anomaly values corresponding to a reversal in the direction of the current transport. In addition, the trend analysis at the 95% confidence level is shown in the bottom-right corner of each diagram. Further details on the product are provided in the corresponding Product User Manual (de Pascual-Collar et al., 2026a) and Quality Information Document (de Pascual-Collar et al., 2026b), as well as in de Pascual-Collar et al., 2024. '''CONTEXT''' The IBI area is a highly complex region characterized by a remarkable variety of ocean currents. Among them, we can highlight those that originate as a result of the closure of the North Atlantic Drift (Mason et al., 2011; Holliday et al., 2008; Peliz et al., 2007; Bower et al., 2002; Knoll et al., 2002; Pérez et al., 2001; Jia, 2000); the subsurface currents flowing northward along the continental slope (de Pascual-Collar et al., 2019; Pascual et al., 2018; Machín et al., 2010; Fricourt et al., 2007; Knoll et al., 2002; Mazé et al., 1997; White & Bowyer, 1997); and the exchange currents occurring in the Strait of Gibraltar and the Alboran Sea (Sotillo et al., 2016; Font et al., 1998; Benzohra & Millot, 1995; Tintoré et al., 1988). The variability of ocean currents in the IBI domain is relevant to the global thermohaline circulation and other climatic and environmental processes. For example, as discussed by Fasullo and Trenberth (2008), subtropical gyres play a crucial role in the meridional energy balance. The poleward salt transport of Mediterranean water, driven by subsurface slope currents, has significant implications for salinity anomalies in the Rockall Trough and the Nordic Seas, as studied by Holliday (2003), Holliday et al. (2008), and Bozec et al. (2011). The Algerian Current serves as the only pathway for Atlantic Water to reach the Western Mediterranean. '''CMEMS KEY FINDINGS''' The volume transport time series reveal periods during which the monitored currents exhibited notably high or low variability. Specifically, the RTE current shows pronounced variability in 2010 and during 2014–2015; the N48 section between 2012 and 2014; the ALG current in 2006 and 2017; the AC current between 2005–2007 and in 2021; and the CC current between 2005–2007. Furthermore, certain periods display anomalies of sufficient magnitude (in absolute value) to indicate a reversal in the net transport direction of the current. This is the case for the ALG current in 2017 and 2024 (with net transport towards the west), and for the CC current in 2010 (with net transport towards the north). Trend analysis over the period 1993–2023 does not reveal any statistically significant trends for the monitored currents. However, the confidence interval for the trend in the ALG section is close to rejecting the null hypothesis of no trend. '''DOI (product):''' https://doi.org/10.48670/mds-00351